Clinicians Pocket Drug Reference 2014 by Gomella Leonard & Haist Steven & Adams Aimee

Author:Gomella, Leonard & Haist, Steven & Adams, Aimee [Gomella, Leonard]
Language: eng
Format: mobi
Publisher: McGraw-Hill Education
Published: 2014-01-10T00:00:00+00:00

Lisdexamfetamine Dimesylate (Vyvanse) [C-II] BOX: Amphetamines have ↑ potential for abuse; prolonged administration may lead to dependence; may cause sudden death and serious CV events in pts w/ preexisting structure cardiac abnormalities Uses: *ADHD* Acts: CNS stimulant Dose: Adults & Peds 6–12 y. 30 mg daily, ↑ qwk 10–20 mg/d, 70 mg/d max w/ P: [C, ?/–] w/ Potential for drug dependency in pt w/ psychological or Sz disorder, Tourette synd, HTN CI: Severe arteriosclerotic CV Dz, mod–severe ↑ BP, ↑ thyroid, sensitivity to sympathomimetic amines, NAG, agitated states, Hx drug abuse, w/ or w/ in 14 d of MAOI Disp: Caps 20, 30, 40, 50, 60, 70 mg SE: HA, insomnia, decreased appetite Notes: AHA statement April 2008: All children diagnosed w/ ADHD who are candidates for stimulant meds should undergo CV assessment prior to use; may be inappropriate for geriatric use

Lisinopril (Prinivil, Zestril) BOX: ACE inhib can cause fetal injury/death in 2nd/3rd tri; D/C w/ PRG Uses: *HTN, CHF, prevent DN & AMI* Acts: ACE inhib Dose: 5–40 mg/24 h PO daily-bid, CHF target 40 mg/d. AMI: 5 mg w/ in 24 h of MI, then 5 mg after 24 h, 10 mg after 48 h, then 10 mg/d; ↓ in renal Insuff; use low dose, ↑ slowly in elderly w/ P: [C (1st tri) D (2nd, 3rd tri), –] w/ Aortic stenosis/cardiomyopathy CI: PRG, ACE inhib sensitivity, idiopathic or hereditary angiodema Disp: Tabs 2.5, 5, 10, 20, 30, 40 mg SE: Dizziness, HA, cough, ↓ BP, angioedema, ↑ K+, ↑ Cr, rare ↓ BM Notes: To prevent DN, start when urinary microalbuminuria begins; BUN, Cr, K+, WBC

Lisinopril & Hydrochlorothiazide (Prinzide, Zestoretic, Generic) BOX: ACE inhib can cause fetal injury/death in 2nd/3rd tri; D/C w/ PRG Uses: *HTN* Acts: ACE inhib w/ diuretic (HCTZ) Dose: Initial 10 mg lisinopril/12.5mg HCTZ, titrate upward to effect; > 80 mg/d lisinopril or > 50 mg/day HCTZ are not recommended; ↓ in renal Insuff; use low dose, ↑ slowly in elderly w/ P: [C 1st tri, D after, –] w/ Aortic stenosis/cardiomyopathy, bilateral RAS CI: PRG, ACE inhib, idiopathic or hereditary angiodema, sensitivity (angioedema) Disp: Tabs (mg lisinopril/mg HCTZ) 10/12.5, 20/12.5; Zestoretic also available as 20/25 SE: Anaphylactoid Rxn (rare), dizziness, HA, cough, fatigue, ↓ BP, angioedema, ↑/↓ K+, ↑ Cr, rare ↓ BM/cholestatic jaundice Notes: Use only when monotherapy fails; BUN, Cr, K+, WBC

Lithium Carbonate, Citrate (Generic) BOX: Li tox related to serum levels and can be seen at close to therapeutic levels Uses: *Manic episodes of bipolar Dz*, augment antidepressants, aggression, PTSD Acts: ?, Effects shift toward intraneuronal metabolism of catecholamines Dose: Adults. Bipolar, acute mania: 1800 mg/d PO in 2–3 ÷ doses (target serum 1–1.5 mEq/L 2×/wk until stable). Bipolar maint: 900–1800/d PO in 2–3 ÷ doses (target serum 0.6–1.2 mEq/L).

Peds ≥ 12 y. See Adults; ↓ in renal Insuff, elderly w/ P: [D, –] Many drug interactions; avoid ACE inhib or diuretics; thyroid Dz, caution in pts at risk of suicide CI: Severe renal impair or CV Dz,

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.